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Prosjektnummer
231014
Toksikologi – laks i mennesker / Organic contaminants in humans after consumption of salmon
Project results
The concentrations of POPs in the salmon fillets were comparable to those typically found in farmed Atlantic salmon. 15 weeks consumption of these fillets was reflected in a significantly increased level of n-3 fatty acids in plasma.
15 weeks consumption of fatty fish did not affect the steady state levels of POPs in the study subjects. Significant associations were found between different plasma long chain fatty acids and different POP classes indicating that the latter have different food products as their main source for human exposure.
The concentrations of POPs in the salmon fillets were comparable to those typically found in farmed Atlantic salmon. 15 weeks consumption of these fillets was reflected in a significantly increased level of n-3 fatty acids in plasma.
15 weeks consumption of fatty fish did not affect the steady state levels of POPs in the study subjects. Significant associations were found between different plasma long chain fatty acids and different POP classes indicating that the latter have different food products as their main source for human exposure.
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Sluttrapport: Draft manuscript: Consumption of farmed salmon did not increase the levels of persistent organic pollutants (POP) in patients with metabolic disorders.
University of Bergen, Institute of Medicine / Haukeland University Hospital, Medical department. November 2008. By Trygve Hausken (University of Bergen, Institute of Medicine / Haukeland University Hospital, Medical department), Rolf K. Berge University of Bergen, Institute of Medicine / Haukeland University Hospital, Department of Heart Disease), Anuschka Polder (Norwegian School of Veterinary Science), Janneche Skaare (Norwegian School of Veterinary Science / National Veterinary Institute Norway), Margaretha Haugen (Norwegian Institute of Public Health), Helle M. Meltzer (Norwegian Institute of Public Health), and Roy M. Nilsen (University of Bergen, Department of Public Health and Primary Health Care).
Background
Advice regarding the health benefits of fish consumption has been complicated by reports that certain fish species like salmon are burdened with levels of organochlorine contaminants (OCs) that may be potentially harmful in man.
Advice regarding the health benefits of fish consumption has been complicated by reports that certain fish species like salmon are burdened with levels of organochlorine contaminants (OCs) that may be potentially harmful in man.
Objectives
To determine changes in the levels of persistent organic pollutants (POP) in human plasma and adipose tissue and to examine associations between POP levels and dietary fat intake during consumption of farmed salmon.
To determine changes in the levels of persistent organic pollutants (POP) in human plasma and adipose tissue and to examine associations between POP levels and dietary fat intake during consumption of farmed salmon.
Expected project impact
As part of a dietary study to examine health effects of a large consumption of salmon in patients with metabolic disorders, it was of interest to assess if it was possible to detect any accumulation of POPs.
As part of a dietary study to examine health effects of a large consumption of salmon in patients with metabolic disorders, it was of interest to assess if it was possible to detect any accumulation of POPs.
Project design and implementation
The 15 week intervention trial was conducted at Haukeland University Hospital, Bergen, Norway during 2005.
Twelve patients with non-alcoholic fatty liver disease consumed 380g farmed Atlantic salmon fillets for 15 weeks in an intervention study to examine the health benefits of farmed salmon. Concentrations of POP: hexachlorobenzene (HCB), bis-2, 2-(4-chlorophenyl) -1,1-trichloroethylene (p,p’-DDE), polychlorinated biphenyls (indicator (id-PCBs), monoortho PCBs (mo-PCBs), polybrominated diphenylethers (PBDEs), were measured in the salmon fillets, and in plasma and abdominal fat biopsies from the patients before and after intervention. Toxicity equivalent quantities (TEQs) for mo-PCBs were calculated.
Ethical approval
The clinical study protocol has been approved by the the Regional Ethics Committee of Western Norway and all the study subjects did sign a written informed consent.
In Norwegian
Plasmaprøver og fettbiopsier fra to ulike grupperinger av forsøkspersoner vil bli analysert for PCB og bromerte flammehemmere samt for tungmetallene bly, kvikksølv og kadmium.
Faktisk gjennomføring
Prøvene som blir analysert stammer fra to ulike studier hvor forsøkspersonene hadde et høyt inntak av laks.
Studie 1
Plasmaprøver (før og etter studieperioden) fra 25 forsøkspersoner som spiste laks 5 dager i uken i 2 x 8 uker. Til sammen 12 kg laks. Laksen var gitt fôr med et høyt innhold av fiskeoljer eller vegetabilske oljer. Sistnevnte laks har et noe lavere innhold av PCB.
Studie 2
Til sammen 58 pasienter (pasientergrupper med artherosklerose, ulcerøs colitt og ikke-alkoholisk fettlever) spiste laks eller tok fiskoljekapsler med tilsvarende fettmengde og utvunnet av den samme laksen. 15 ukers studieperiode. Laksespising 2 dager i uken, til sammen 6 kg laks.
Totalt ble 200 plasmaprøver og 25 fettvevsbiopsier analysert laksens innhold av de samme forbindelser ble også analysert.
The 15 week intervention trial was conducted at Haukeland University Hospital, Bergen, Norway during 2005.
Twelve patients with non-alcoholic fatty liver disease consumed 380g farmed Atlantic salmon fillets for 15 weeks in an intervention study to examine the health benefits of farmed salmon. Concentrations of POP: hexachlorobenzene (HCB), bis-2, 2-(4-chlorophenyl) -1,1-trichloroethylene (p,p’-DDE), polychlorinated biphenyls (indicator (id-PCBs), monoortho PCBs (mo-PCBs), polybrominated diphenylethers (PBDEs), were measured in the salmon fillets, and in plasma and abdominal fat biopsies from the patients before and after intervention. Toxicity equivalent quantities (TEQs) for mo-PCBs were calculated.
Ethical approval
The clinical study protocol has been approved by the the Regional Ethics Committee of Western Norway and all the study subjects did sign a written informed consent.
In Norwegian
Plasmaprøver og fettbiopsier fra to ulike grupperinger av forsøkspersoner vil bli analysert for PCB og bromerte flammehemmere samt for tungmetallene bly, kvikksølv og kadmium.
Faktisk gjennomføring
Prøvene som blir analysert stammer fra to ulike studier hvor forsøkspersonene hadde et høyt inntak av laks.
Studie 1
Plasmaprøver (før og etter studieperioden) fra 25 forsøkspersoner som spiste laks 5 dager i uken i 2 x 8 uker. Til sammen 12 kg laks. Laksen var gitt fôr med et høyt innhold av fiskeoljer eller vegetabilske oljer. Sistnevnte laks har et noe lavere innhold av PCB.
Studie 2
Til sammen 58 pasienter (pasientergrupper med artherosklerose, ulcerøs colitt og ikke-alkoholisk fettlever) spiste laks eller tok fiskoljekapsler med tilsvarende fettmengde og utvunnet av den samme laksen. 15 ukers studieperiode. Laksespising 2 dager i uken, til sammen 6 kg laks.
Totalt ble 200 plasmaprøver og 25 fettvevsbiopsier analysert laksens innhold av de samme forbindelser ble også analysert.
Dissemination of project results
The project group aims to present results from the project in several peer-reviewed international journals.
The project group aims to present results from the project in several peer-reviewed international journals.
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Sluttrapport: Draft manuscript: Consumption of farmed salmon did not increase the levels of persistent organic pollutants (POP) in patients with metabolic disorders.
University of Bergen, Institute of Medicine / Haukeland University Hospital, Medical department. November 2008. By Trygve Hausken (University of Bergen, Institute of Medicine / Haukeland University Hospital, Medical department), Rolf K. Berge University of Bergen, Institute of Medicine / Haukeland University Hospital, Department of Heart Disease), Anuschka Polder (Norwegian School of Veterinary Science), Janneche Skaare (Norwegian School of Veterinary Science / National Veterinary Institute Norway), Margaretha Haugen (Norwegian Institute of Public Health), Helle M. Meltzer (Norwegian Institute of Public Health), and Roy M. Nilsen (University of Bergen, Department of Public Health and Primary Health Care).